Stein family impact on avant-garde French art on show (Reuters)
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It is tricky to classify a specific design in the class of good design or bad design, as there are multiple factors that the success of a graphic designing rests. While art concerns private interpretation of the things and so is subjective, graphic designs serve a specific function. A single design can do all of the speaking for the product. Graphic planning is really necessary in the entertainment sector as it a strong storytelling gizmo.
A good graphic designing artist will simply connect to what his customer is asserting and can even supply a good drawing or picture based primarily on what the customer is describing. Client Communication Putting into paper the concept of the shopper is one thing, but to be well placed to communicate simply with the customer is another. He might be able to bring out all of the best concepts of his clients and be in a position to suggest his very own also.
While it is always you who will have the final say, he remains the pilot of the entire project and he should take charge. The graphical design on one hand surpasses the range of the projects of Net. The arrangement of the text and visible should be properly visualized outside since a good present can make a better impact of page. More than the mix of colors and the fonts in a visually pleasing page, the provision is of superior signification in the graphic designing. The problem by making reports and tasty designs could be the signification of the relentless production of the creative designs. Any effective design is made by first considering the audience.
Graphical designers must be not only artists, but also highly pro people who pay great awareness of detail while understanding what their customer is trying to realize. Will the images used appeal to the precise group or groups of folks you are making an attempt to reach? And, just as important, is the message that?s being conveyed clear and easy to comprehend? Good graphic designing is the results of the designer having the power to imagine themselves as a mean member of the target audience.
Does the design galvanize? Provoke? Does it follow with the client?s existing branding or image? And, is the text simple to see and read? When photography is part of the equation, good design includes photographs that are wonderfully clear and free of any pixelization or unintended blurred edging.
Here?s where internships come in. Internships give those that are nearing graduation or people who have just latterly graduated an opportunity to experience what it is like in that selected career field. There are particular abilities that are wanted by potential companies and it?s thus significant for interns to have data in those areas. Some of the software that interns may want to be familiar with includes Abode Photoshop and Illustrator, HTML, Flash, and Microsoft Office.
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Perhaps you are feeling anxious or depressed. You may be upset by a divorce or separation or a recent loss of someone close. If so, e-couch may help you work through your feelings.
One in five people have an emotional problem in any twelve month period...
...so the site is designed for lots of people!
Your e-couch program includes information, exercises and a workbook to track your progress and record your experiences, and toolkits to help you improve your mood and emotional state, and tackle challenges that you may be facing.
e-couch is a free self-help interactive program with modules for depression, generalised anxiety & worry, social anxiety, relationship breakdown, and loss & grief.
It provides evidence-based information and teaches strategies drawn from cognitive, behavioural and interpersonal therapies as well as relaxation and physical activity.
e-couch is provided by the folks at the Australian National University.
Source: http://www.selfhelpfreebies.com/2012/02/dealing-with-depression-anxiety-or.html
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ScienceDaily (Feb. 27, 2012) ? Why is it that Mycobacterium tuberculosis can cause tuberculosis with as little as 10 cells, whereas Vibrio cholerae requires the host to ingest up to tens of millions of cells to cause cholera? This is the question that two research teams, from the Pasteur Institute, in France, and the Instituto Gulbenkian de Ciencia and the University of Lisbon, in Portugal, answer in the latest issue of the journal PLoS Pathogens.
The researchers show that bacteria that are able to invade and/or destroy cells of the host's immune system have higher infectivity, whereas those that are more motile, multiply faster and communicate with each other are less infectious, that is, it takes more bacterial cells to trigger an infection. These findings help understand the patterns that shape infectivity of bacteria, and contribute to more accurate predictions of how emerging pathogens may evolve, with implications for public health. Despite the multitude of mechanisms that pathogens use to exploit its human host, the research teams of Eduardo Rocha, in France, and Francisco Dion?sio, in Portugal, set out to find common themes in the mechanisms used by distantly related bacteria.
The researchers trawled through scientific literature on 48 bacterial pathogens. They related several bacterial features (motility, interactions with the immune system, growth rate) with their value of ID50 -- the minimum number of bacterial cells that is required to trigger an infection in 50% of infected hosts. The teams found that bacteria that are able to destroy or subvert phagocytes -- the cells of the immune system that engulf bacteria -- have ID50 of around 250 cells. The remaining bacteria, meanwhile, have ID50 values of around 30 million -- they are much less infectious.
These bacteria rely on high turnover (or growth), are very motile, and are capable of communicating with other bacteria, through the mechanism of quorum-sensing. Says Joao Gama, first author of the paper, "In the "arms race" between disease-causing bacteria and the hosts they infect, some bacteria act through frontal attack, whereas others operate through stealth, manipulating the host's immune system. Many others are somewhere in between. Our findings suggest that the low ID50 (more infectious) bacteria be classed as working by stealth; the high ID50 bacteria are those that resort to frontal attacks."
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Source: http://www.sciencedaily.com/releases/2012/02/120227094132.htm
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Published on Saturday 25 Feb 2012 14:11
A investigate of a new drug for modernized skin cancer has shown it ?almost doubles presence times?, BBC News has reported.
The drug, called vemurafenib, was tested in a clinical hearing that examined a impact on swelling distance and presence in patients with modernized cancer skin cancer that had widespread to other tools of a body. The opinion for this form of cancer is generally bad as it?s an assertive cancer with few diagnosis options and patients tend to tarry for rebate than a year. Researchers found that approximately half of a patients responded to a drug and that a altogether presence rate in these patients was scarcely 16 months, on average.
This investigate provides justification on a efficacy of a new drug, vemurafenib, for treating some patients with metastatic melanoma. Because a drug works by targeting a specific genetic mutation, it won?t be suitable for patients who aren?t carrying a mutation, that is found in around half of patients with cancer that has spread. Additionally, while a drug has been endorsed for approval, it hasn?t nonetheless been authorized for use in Europe; it is misleading during this indicate if and when it will be accessible for diagnosis in a UK, nonetheless a National Institute for Health and Clinical Excellence (NICE) is pronounced to be now assessing it.
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The investigate was carried out by researchers from Vanderbilt University, a Hoffman-La Roche curative association and other institutions via a US and Australia. The investigate was upheld by Hoffmann-La Roche, who are the?manufacturers of?vemurafenib.
The investigate was published in a peer-reviewed?New England Journal of Medicine.
The BBC lonesome this investigate appropriately, emphasising a certain formula though also highlighting that a drug had nonetheless to be authorized in a UK and wouldn?t be suitable for all patients with metastatic melanoma. The broadcaster also reported on some of a stipulations of a investigate methods.
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This was a?phase II clinical hearing that examined how effective a drug called vemurafenib was during inducing a clinical response and a impact on altogether presence in a set of patients with metastatic melanoma. Malignant cancer is a comparatively singular though assertive form of skin cancer that can be quite tough to provide when held during an modernized stage. All of a patients in a hearing carried a specific genetic turn called a ?BRAF V600 mutation?, that leads to a aberrant activation of an enzyme concerned in dungeon expansion and death. Previous investigate indicates that vemurafenib blocks a movement of this enzyme.
Phase II trials are designed to consider a effects of new drugs in rarely tranquil settings. These trials don?t routinely occupy a organisation of?control patients receiving other forms of treatment, and so generally can?t be used to tell how a new drug compares opposite customary or existent treatments. These forms of control-group comparisons are customarily achieved in proviso III trials. Phase II trials are, however, a pivotal prejudiced of a growth of new drugs, and are used as a assenting step before a drug can be given to wider investigate populations.
Media coverage of this hearing has compared a presence rates of patients receiving vemurafenib with those seen in ubiquitous patients with metastatic melanoma, rather than patients directly concerned in a study. While such comparisons are useful for readers to know some-more about a drug, grave systematic comparisons of opposite treatments have to comment for a operation of critical factors, such as patients? medical histories or how modernized a cancer is when diagnosis is started.
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Researchers enrolled 132 patients with theatre IV metastatic cancer (stage IV cancer means it has widespread to other tools of a body, such as a lungs or liver). They all carried a form of BRAF V600 genetic mutation. All patients had formerly been treated for a disease, and they all perceived a same sip of a drug vemurafenib twice a day. The patients stopped holding a drug if they gifted unsuitable side effects or if their illness progressed.
The patients underwent swelling imaging (either captivating inflection imaging (MRI) or computed tomography (CT)) during a commencement of a investigate and each 6 weeks thereafter. Researchers used these scans to consider any changes in swelling distance and response to a treatment.
Researchers afterwards analysed a information to establish a suit of patients who responded to treatment.
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The patients were followed adult for an normal (median) of 12.9 months. The researchers found that:
Most patients gifted during slightest one side outcome due to a investigate drug. The many ordinarily reported side effects were corner pain, rash, fatigue, attraction to light and hair loss. Four patients (3%) stopped holding a drug due to side effects. One studious died due to a fast course of a cancer along with kidney failure; a researchers pronounced this might have been associated to holding vemurafenib though this was not certain.
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The researchers resolved that vemurafenib effectively targets metastatic cancer tumours in patients with BRAF V6000 mutations, and that response rates are aloft than those seen with other treatments.
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This investigate has shown that patients with a specific turn and modernized metastatic cancer have a high response rate to a new drug, vemurafenib. Currently, diagnosis options for people with metastatic cancer can engage chemotherapy, radiotherapy or defence therapies, though even with diagnosis a opinion is customarily bad once their cancer has spread. Often, people with late-stage illness might be enrolled in clinical trials such as this to try and find some-more effective treatments.
Researchers contend that a prolonged follow-up of their investigate provides initial justification on a altogether presence of patients receiving this drug, something that proviso III studies have so distant not been means to demonstrate.
Researchers indicate out, however, that patients do rise insurgency to vemurafenib, and that serve investigate is indispensable to establish how this occurs.
Previous studies have shown that patients with metastatic cancer have an normal presence rate of 6 to 10 months, as mentioned in some news coverage. However, it is formidable to review this guess to presence times seen in a stream study, as a studious populations might be different. For example, it?s misleading either these studies enrolled patients with a same genetic mutation, or how presence might be opposite between those with and but a mutation.
This investigate adds to a ascent justification of a efficacy of vemurafenib as a diagnosis of metastatic cancer with BRAF V600 mutation. While this proviso II investigate can't directly denote efficacy compared to customary care, an additional proviso III investigate has been conducted that randomised patients to accept vemurafenib or customary therapy. This investigate was stopped before it was complete, as an halt investigate indicated that vemurafenib significantly softened patients??progression-free presence and six-month survival, compared?with customary care. At this point, all of a participants were given a new drug.
All in all, this is really earnest investigate for a diagnosis of an assertive cancer for that there are few existent options. At benefaction a drug has been endorsed for capitulation by a European Medicines Agency, and is now being evaluated by NICE for use in a UK.
Analysis by Bazian
Source: http://www.stage-4-cancer.com/new-skin-cancer-drug-performs-well/
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Youtube link for mobile viewing
Acer's brought its brand-new entry level Liquid Glow smartphone here to Mobile World Congress. Not a whole lot to write home about -- 3.7-inch display and a 5MP camera. But it's available in pink, white or black and has NFC. So it's got that going for it, which is nice.
The Acer Liquid Glow will be available this summer.
Source: http://feedproxy.google.com/~r/androidcentral/~3/dtn-4Vwejs0/story01.htm
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Source: lubbockonline.com --- Saturday, February 25, 2012
Murders and shooting deaths are an unfamiliar occurrence in Slaton. The town of 6,121 is haunted by murder only once a decade, at most, the city?s Mayor said and Avalanche-Journal archives show. And they?re certainly unwelcome every time. But Slaton residents gathered early Saturday to mourn the second violent death in their town in less than a month and just after the still-recovering victims from last month?s deadly shooting returned home. read more ...
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Big Coal and Big Oil know that, in their business, political friends are worth their weight in gold. An academic study of one case of corporate lobbying estimated the return on investment at 22,000 percent: a dollar spent earned $220. Jack Abramoff, the convicted, influence-peddling super-lobbyist, pegged the return on investment of one project at 100,000 percent: $4 million dollars in lobbying cash purchased a $4 billion tax break for Tyco International.
Inspired by paybacks like those, the dirty-energy industry lavishes money on campaigns and lobbying. Not surprisingly, among its favorite sons are Rep. Joe Barton (R-Texas), who famously apologized to BP for Congress?s criticism during the Gulf oil disaster, and Sen. James Inhofe (R-Oklahoma), who insists the science of global warming is a hoax and has likened the US Environmental Protection Agency to the Gestapo. Rep. Barton has raked in $1,914,183 and Sen. Inhofe $1,287,950 from Big Coal and Oil?amounts that bring to mind social critic Upton Sinclair?s observation: ?It is difficult to get a man to understand something when his salary depends upon his not understanding it.?
But what about Cascadia, with our hydropower and wind turbines, energy efficiency and smart growth? Does the lucre of Big Coal and Oil taint our delegation to Congress too? We pulled the numbers from the Dirty Energy Money Campaign, which compares recent Congressional votes on a dozen indicative energy policy issues with campaign contributions from fossil energy companies. The answer is unpleasant: even in the Northwest, Big Coal and Oil are dumping train loads of cash on our democracy?almost $5 million since 1999?and the main recipients are hewing to the dirty-energy line. These figures actually understate dirty-energy political money dramatically. They reflect campaign contributions made by energy companies and their key? employees. They ignore contributions made by major investors in these companies and the huge sums of political money that filter to candidates or their election through the bank accounts of lobbyists, PACs, and Super-PACs. Think of these figures as the tip of the iceberg: the visible part but not the most dangerous part.
In the figure below, Cascadia?s representatives in the US House of Representatives and Senate appear by state and party. Their contributions since 1999 from coal and oil companies show up as the length of their bar, and the percentage listed with each bar displays the share of the time that they have sided with the fossil-fuel interests in twelve key votes. Seven of the top eight recipients of dirty-energy political dollars voted with Big Coal and Oil 100 percent of the time. Of the twelve who received the least dirty-energy money, nine never voted with Big Coal and Oil, two voted with them just once, and only one voted the Big Coal and Oil line.

In the Northwest, Alaska and Montana are the main oil and coal producers, and their delegates get the vast majority of political money from Big Coal and Oil. As the figure below shows, the average Alaskan member of Congress has received more than five times as much as the average Oregon member. Until recently, Washington and Oregon have not been major players in the fossil-energy industry; however, with the coal-export debate raging, more coal cash may infiltrate the states.

Contributions may also swing from oil to coal interests. In the past, oil?with its higher profits?has been the bigger gusher of political money, as the figure below illustrates.

Dirty-energy political money flows from a long list of companies. ExxonMobil leads the contributors to members of the current Congress, followed by Koch Industries and Chevron. Among the top ten (shown above) are also well known petroleum companies such as ConocoPhillips and BP. Less-familiar names include Fluor, which does engineering, construction, maintenance, and the like for big energy companies; it also does work at the Hanford Nuclear Reservation in Central Washington. The Southern Company owns power utilities that burn a lot of coal in Georgia and other southern states. Williams is a giant, Oklahoma-based natural gas company.

These ten companies accounted for about 30 percent of all dirty-energy political contributions made since 1999 to incumbent members of Congress from the Pacific Northwest. Each state has its own particular mix; for example, the top contributor in Montana is PPL, which does not support any politicians in Washington State. PPL, among other things, is part owner of the enormous Colstrip coal-fired power complex that sells electricity into Cascadia from eastern Montana.
Members of the Republicans Party get three times more dirty-energy money than do Democrats. The average Republican hauled in over $300,000 in donations from Big Coal and Oil, with Alaska Senator Lisa Murkowski receiving the most at nearly $1 Million, more than all contributions to Washington State?s Senators and Representatives combined. In contrast, Democrats averaged less than $100,000 each, a number that drops to $54,000 if we exclude Montana?s senior senator Max Baucus, who has received $661,000 since 1999.
If we were to take the standard view on this issue, we would expect a direct correlation between the amount of political money a politician received from Big Oil and Coal, and the way she or he voted on subsequent legislation. But as Lawrence Lessig establishes in his new book Republic, Lost, that?s not how money corrupts our democracy. The process is more subtle and ruinous: politicians, who spend more time fundraising than doing any other single waking activity, develop a sixth sense for their funders? interests. Their positions on issues often lean toward money long before they even solicit contributions from a source. As former lobbyist Jimmy Williams observes, incumbents often reach out to lobbyists in order to finance their re-elections. Many use their voting record to demonstrate their commitment to the cause.
Not surprisingly, given the intense political polarization sweeping the United States, voting records correlated even more closely with party than dollars received. Ten of eleven Republicans voted with dirty energy 100 percent of the time, and the eleventh did so 58 percent of the time. Of the sixteen Democrats, thirteen voted against dirty energy every time, two did more than 90 percent of the time, and the last did 75 percent of the time.
The dirty-energy political money we?ve documented here is the tip of the iceberg. Our figures ignore the millions that companies and their owners give to lobbyists, PACs, and Super-PACs. It ignores contributions to state and local races and on ballot measures (such as this cynical and anti-democratic one). But even without a full view of the ledger, the conclusion is troubling: Big Coal and Big Oil have spent almost $5 million on campaign contributions to the current US Congressional Delegation from Cascadia, a region that prides itself as an emerging leader in the clean-energy economy.
Sources and Notes: Data from the Center for Responsive Politics with additional analysis by Oil Change International. Throughout the article and in all figures, the contributions reported are total receipts since 1999 of the Northwest?s current Congressional delegation, including both US Senators and Representatives. No data were available for Rep. Susan Bonamici (D-Oregon), who only recently took the seat vacated by David Wu when he resigned in August 2011. One of the main contributors to politicians of both parties in all states was the National Rural Electric Cooperative Association. In much of the United States, rural electric coops support fossil energy. In Cascadia, however, they use primarily hydropower and have a mixed lobbying stance on fossil fuels. We therefore removed NRECA from the data set.
Guest contributor Japhet Koteen is a community builder, urbanist, and real-estate developer in Seattle.
Source: http://daily.sightline.org/2012/02/23/dirty-energy-money/
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This comprehensive and easy-to-use guide is an invaluable resource to help you choose a rewarding counseling career that best suits your interests, strengths, and personality. Exploring a wealth of career opportunities in both traditional and non-traditional settings, including the most exciting emerging fields, this useful reference describes the many benefits found in the work of a professional counselor. Each career listing includes an overview, salary range, employment prospects, best and most challenging aspects of the job, and educational and licensing requirements. In addition, the book helps guide you through financing your education and the job search process. As a special feature, chapters include profiles of actual counselors and their work, providing an insightful insider?s perspective on their profession.
Key Features:
This comprehensive and easy-to-use guide is an invaluable resource to help you choose a rewarding counseling career that best suits your interests, strengths, and personality. Exploring a wealth of career opportunities in both traditional and non-traditional settings, including the most exciting emerging fields, this useful reference describes the many benefits found in the work of a professional counselor. Each career listing includes an overview, salary range, employment prospects, best and most challenging aspects of the job, and educational and licensing requirements. In addition, the book helps guide you through financing your education and the job search process. As a special feature, chapters include profiles of actual counselors and their work, providing an insightful insider?s perspective on their profession.
Key Features:
Source: http://bookvisa.com/education/3097/
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